I have a goal of eliminating all current uses MMB because there isn't really a good button on most computer's mouse, just a scroll wheel that clicks. Eliminating them isn't easy to do.
First some background:
The original Alt+RMB was added because in those days many computers had a 2-button mouse without a wheel. Then it was impossible to do things like deselect a single object. But now all computers have a wheel so the Alt solution isn't 100% necessary.
I realize that this is a break with user-interface compatibility but feel that it has tremendous advantages. It's much easier to pan, zoom, rotate your view when modeling without interrupting your work flow.
Why eliminate (re-purpose) the MMB?
For experienced modelers, being able to fluidly view your model from different angles is very important. What I'd like to do is add panning to the wheel as well as zooming. You could click-drag with the MMB to pan around your model and scroll the wheel at the same time to enlarge of reduce the view. 3DS Max does this and it's very, very useful.
What about tablets?
This is a huge problem of design. I do want to make all the functionality available to touch-screen interfaces but it will necessarily be a different UI. Anim8or runs fine on my Surface 3 but, obviously, a lot of things aren't accessible. Something left to do after v1.0 is out.