Antialiasing is fine when you're not editing. But it's a hassle when you get into photo shop and go to select an area of color and you get spotty edges. I've worked on projects that have required pixel perfect accuracy and the kind of "halo" effect you get on aliased images list the last thing you want to deal with.
Alpha2: I know what you mean, but when I must edit in PS a final render from anim8or, or for that matter any image, I use channel masks or simple matte masks. Usually, selecting a color area with the select tool is never recommended, and it never gives good results. Indeed, a fix for this would be a huge render export from anim8or, and after size it down the aliasing would be gone. But since the max is 4K, the best approach would be matte or channel masks for PS edits.